The Miami Marlins (50-55) head to Busch Stadium to face the St. Louis Cardinals (55-53) on Wednesday night in a matchup featuring two starters with questionable road and home splits respectively.
Cal Quantrill (3-8, 5.05 ERA) takes the mound for the road-strong Marlins offense that ranks 5th in scoring away from home, while Miles Mikolas (6-7, 4.94 ERA) looks to leverage his significantly better home performance for the Cardinals.
With St. Louis holding a 7-3 edge in their last ten meetings and both pitchers showing vulnerability according to advanced metrics, this midweek showdown promises plenty of scoring opportunities for both sides.
St. Louis Cardinals vs. Miami Marlins prediction: who will win?
For tonight's St. Louis Cardinals vs Miami Marlins matchup, our predictive model gives the Marlins a 72.5% chance of defeating the Cards.
St. Louis Cardinals: 27.5% win probability
- Struggling home record (4-11 in their last 15 at Busch Stadium)
- Offensive production issues (averaging just 3.2 runs over their last 12 games)
- Pitching inconsistency (5.74 ERA from starting rotation in July)
Miami Marlins: 72.5% win probability
- Dominant road performance (15-7 in last 22 away games)
- Superior batting efficiency (.275 team average, ranking 3rd in MLB)
- Excellent bullpen management (3.21 ERA in late-inning relief situations)
At Sporting Post, our custom prediction model blends insights from leading MLB analysts to give you a clear edge.
Instead of sorting through endless opinions, we streamline expert picks, advanced team metrics, and market trends into one place. Our AI tracks top sources and assigns a confidence score to each prediction. These are averaged into a win probability that reflects the expert consensus. It gives you a data-backed view of what the sharpest minds in MLB expect.
| St. Louis Cardinals | Miami Marlins | |
|---|---|---|
| Moneyline |
St. Louis Cardinals vs. Miami Marlins preview
The Marlins roll into Busch Stadium riding some momentum after taking two of three from Milwaukee, but they'll face a Cardinals team desperate to gain ground in a tight NL Wild Card race.
Miami's offense has been surprisingly potent on the road this season, averaging nearly five runs per game away from home – a stark contrast to their struggles at loanDepot Park.
Both starting pitchers enter with something to prove: Cal Quantrill (3-8, 5.05 ERA) has been particularly vulnerable on the road with a bloated 5.76 ERA, while the Cardinals' Miles Mikolas (6-7, 4.94 ERA) has been much sharper at home, sporting a respectable 3.75 ERA in the friendly confines of Busch Stadium.
St. Louis has dominated this matchup historically, winning seven of the last ten meetings, though their recent 4-6 stretch has opened the door for Miami to potentially steal a series opener.
The advanced metrics suggest neither starter has been particularly effective this season, with both ranking in the bottom 20th percentile in expected ERA and barrel percentage – setting the stage for what could be an offensive showcase in St. Louis.
St. Louis Cardinals vs. Miami Marlins form
St. Louis Cardinals vs. Miami Marlins head to head
St. Louis Cardinals
80%
Miami Marlins
20%
Jul 28, 2025
St. Louis Cardinals
7 : 1
Miami Marlins
Mar 22, 2025
Miami Marlins
2 : 8
St. Louis Cardinals
Mar 18, 2025
St. Louis Cardinals
4 : 4
Miami Marlins
Mar 16, 2025
Miami Marlins
11 : 5
St. Louis Cardinals
Mar 11, 2025
St. Louis Cardinals
5 : 12
Miami Marlins
Mar 2, 2025
Miami Marlins
5 : 3
St. Louis Cardinals
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