The Chicago Cubs enter Saturday's divisional clash with the St. Louis Cardinals riding momentum from their season series lead but facing pressure after falling four games behind Milwaukee in the NL Central.
Colin Rea takes the mound for Chicago looking to bounce back from recent struggles, while Andre Pallante gets the nod for St. Louis as the Cardinals fight to stay within striking distance of a wildcard spot.
With both teams averaging over eight runs combined per game in their season matchups and key offensive weapons heating up on both sides, this Busch Stadium showdown could determine which club gains crucial ground in the playoff race.
St. Louis Cardinals vs. Chicago Cubs prediction: who will win?
For tonight's Cardinals vs Cubs matchup, our predictive model gives the Cubs a 75% chance of defeating the Cardinals.
St. Louis Cardinals: 25% win probability
- Poor recent form going 2-3 in last 5 games (WWLWL pattern)
- Defensive struggles allowing 4.5 runs per game (525 runs allowed)
- Below .500 record at 59-58 puts them 4th in competitive NL Central
Chicago Cubs: 75% win probability
- Superior record with 66-49 (.574) compared to Cardinals' 59-58 (.504)
- Explosive offense averaging 5.0 runs per game (588 runs in 115 games)
- Strong divisional position sitting 2nd in NL Central, 7 games ahead of Cardinals
At Sporting Post, our custom prediction model blends insights from leading MLB analysts to give you a clear edge.
Instead of sorting through endless opinions, we streamline expert picks, advanced team metrics, and market trends into one place. Our AI tracks top sources and assigns a confidence score to each prediction. These are averaged into a win probability that reflects the expert consensus. It gives you a data-backed view of what the sharpest minds in MLB expect.
St. Louis Cardinals | Chicago Cubs | |
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St. Louis Cardinals vs. Chicago Cubs preview
The Cubs arrive in St. Louis riding high at 66-48 and holding the NL's first wildcard spot, but they're feeling the heat after dropping four games behind Milwaukee in the division race.
Colin Rea takes the mound for Chicago despite some recent struggles, having allowed 11 runs over his last three starts, though he's been solid against St. Louis historically with a respectable 3.89 ERA in previous matchups.
The Cardinals sit at .500 and face an uphill climb at 5.5 games out of wildcard contention, with Andre Pallante getting the start despite posting a concerning 5.16 ERA in July and going just 1-5 in his last six outings.
Chicago's offense has been clicking all season, leading MLB with 5.16 runs per game, while Seiya Suzuki has been locked in this month with a .950 OPS to complement his 27 homers and 84 RBIs.
St. Louis will lean heavily on Willson Contreras, who's been scorching hot in August with a 1.056 OPS, though they'll miss Nolan Arenado's bat as the veteran third baseman remains sidelined with injury.
With the Cubs having won four of seven meetings this season and both starting pitchers showing recent vulnerability, expect fireworks at Busch Stadium in what could be a pivotal game for Chicago's divisional hopes.
St. Louis Cardinals vs. Chicago Cubs form


St. Louis Cardinals vs. Chicago Cubs head to head

St. Louis Cardinals
50%

Chicago Cubs
50%
Aug 9, 2025
St. Louis Cardinals
5 : 0
Chicago Cubs
Jul 6, 2025
Chicago Cubs
11 : 0
St. Louis Cardinals
Jul 5, 2025
Chicago Cubs
6 : 8
St. Louis Cardinals
Jul 4, 2025
Chicago Cubs
11 : 3
St. Louis Cardinals
Jun 26, 2025
St. Louis Cardinals
0 : 3
Chicago Cubs
Jun 25, 2025
St. Louis Cardinals
0 : 8
Chicago Cubs
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