Detroit Tigers vs Minnesota Twins Prediction, Odds, MLB Picks 8/4/2025

The Detroit Tigers (65-47) look to extend their five-game hot streak and widen their AL Central lead as they host the struggling Minnesota Twins (51-59), who have dropped six of their last seven contests.

Casey Mize (9-4, 3.43 ERA) takes the mound for Detroit against Minnesota's Simeon Woods Richardson (5-4, 4.24 ERA) in what sets up as a pivotal pitching matchup at Comerica Park.

With the Tigers' offense clicking at nearly five runs per game and Minnesota's recent roster overhaul signaling a rebuild, Detroit appears well-positioned to continue their divisional dominance in Monday's series opener.

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Detroit Tigers vs. Minnesota Twins preview

The red-hot Tigers, winners of five of their last six games, look to extend their eight-game lead in the AL Central as they welcome a floundering Twins squad to Comerica Park on Monday night.

Casey Mize (9-4, 3.43 ERA) takes the mound for Detroit against Minnesota's Simeon Woods Richardson (5-4, 4.24 ERA) in what's shaping up as a lopsided matchup given the teams' divergent trajectories.

Minnesota has lost six of their last seven games and appears to be in full rebuild mode after trading away 40% of their roster at the deadline, while Detroit's offense continues to click, averaging nearly six runs per game over their last three outings.

Tigers slugger Riley Greene (26 HR, 84 RBI) and midseason acquisition Gleyber Torres (.277 average) have powered Detroit's sixth-ranked offense, which should find opportunities against a Twins pitching staff that sits 22nd in team ERA.

Despite Minnesota's struggles, Byron Buxton remains a bright spot with his team-leading .282 average, 23 homers, and 59 RBI, though he'll face a tough challenge against Detroit's top-10 pitching staff.

The Tigers and Twins have split their last ten meetings, but Detroit's surging momentum and home-field advantage make them the clear favorite in this AL Central showdown.

Key stats

1

Detroit Tigers sit second in the American League with a strong 65-48 record (.575) and are on a positive 3-2 run in their last five games (LWLWW)

2

Minnesota Twins rank 12th in the American League with a 52-59 record (.468) and have lost four of their last five games (WLLLL)

3

Tigers boast the fourth-best offense in the American League with 543 runs scored while allowing just 463 runs (second-best run differential in AL)

4

The Twins have struggled defensively, allowing 496 runs while scoring 462, resulting in a -34 run differential that ranks ninth in the American League

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