Southampton vs Manchester City Prediction, Odds & Betting Tips

Manchester City will look to extend their commanding record against bottom-placed sides when they visit Southampton this Saturday, having won their last 12 matches against teams starting the day at the foot of the table by a staggering 44-1 aggregate score.

The Saints, who have lost 28 league games this season and possess both the worst attacking and defensive records in the Premier League, face a City side that has kept clean sheets in five of their last seven matches across all competitions.

With Kevin De Bruyne boasting an impressive record of five goals and 11 assists against Southampton throughout his career, Pep Guardiola's men appear primed to secure three vital points in their push for Champions League qualification.

Southampton vs. Manchester City prediction: who will win?

For today's Southampton vs Manchester City matchup, our predictive model gives the Citizens a 85% chance of defeating the Saints.

Manchester City: 85% win probability

Excellent recent form (WWWWD in last 5 matches showing strong momentum)
Potent attacking record (67 goals scored this season, the 3rd best in the league)
Top-tier league position (3rd place with 64 points, fighting for Champions League spots)

Southampton: 15% win probability

Dismal league position (20th place with just 11 points from 35 matches)
Terrible defensive record (82 goals conceded, the worst in the league)
Poor recent form (LLDLL in last 5 matches showing continued struggles)

At Sporting Post, our unique prediction model harnesses insights from top Premier League football experts. Instead of scouring hundreds of analyses across the web, you can rely on our predictions to gauge the market's overall sentiment. We scan trusted sources, analysing football predictions, statistics, and expert opinions, and our AI assigns a confidence level to each prediction. These confidence levels are then averaged to create an 'expert opinion' win probability—capturing the collective intelligence of the football industry's most respected Premier League analysts.

Southampton vs. Manchester City odds

Here are the latest odds for the Premier League fixture between Southampton (home) and Manchester City (away) set to take place on Saturday, May 10.

	Southampton	Manchester City	Draw
Match Result	12/1 (via William Hill)	1/5 (via Betway UK)	6/1 ( via Betway UK)

Southampton vs. Manchester City preview

Southampton's nightmare Premier League campaign staggers toward its inevitable conclusion as they welcome Manchester City to St Mary's in a David versus Goliath clash that few give the hosts any hope of winning.

The Saints, anchored to the bottom of the table with a staggering 28 defeats and the worst attacking and defensive records in the division, represent the perfect opportunity for Pep Guardiola's men to continue their recent resurgence.

City arrive unbeaten in their last 29 meetings against bottom-placed teams and have won their last 12 such encounters by a devastating aggregate score of 44-1.

Kevin De Bruyne, who has enjoyed tormenting Southampton throughout his career with five goals and eleven assists against them, will be looking to add to his impressive tally after netting the winner against Wolves last time out.

The visitors have tightened up defensively with clean sheets in five of their last seven matches and appear well-positioned to secure a comfortable victory that would strengthen their grip on a Champions League qualification spot.

Simon Rusk's Southampton, desperately trying to avoid matching Derby County's record low points total, face an uphill battle with injuries to Juan Larios and Gavin Bazunu further weakening an already fragile squad.

Southampton vs. Manchester City betting tips

Manchester City To Win To Nil (13/10)

Manchester City @ Southampton

Manchester City's defensive prowess has been remarkable lately, with clean sheets in five of their last seven fixtures across all competitions.

The Saints looked toothless in attack during their recent 2-0 defeat against Leicester, suggesting they'll struggle to breach City's well-organized backline.

Pep Guardiola's men are in the thick of a title race and simply cannot afford any slip-ups at this stage of the season.

City have conceded just 33 goals in 35 Premier League matches this campaign, highlighting their defensive solidity.

Southampton's relegation has already been confirmed, potentially dampening their motivation while City remain laser-focused on securing maximum points.

Manchester City to Win 3-0 (8/1)

Manchester City @ Southampton

The specific 3-0 scoreline for City appears particularly likely given Southampton's defensive frailties this season.

The relegated Saints have conceded exactly three goals on 14 separate occasions across all competitions this campaign, establishing a clear pattern.

Manchester City's attacking machinery continues to operate at peak efficiency as they chase another Premier League title.

Southampton's defensive shortcomings, combined with City's need for maximum points, creates perfect conditions for a comfortable away victory.

This scoreline would align perfectly with City's methodical approach to dispatching lower-table opponents without expending unnecessary energy.

Kevin De Bruyne To Score Anytime (2/1)

Manchester City @ Southampton

Kevin De Bruyne has developed a remarkable record against Southampton, contributing more goals against them than any other Premier League opponent.

The Belgian maestro has accumulated an impressive five goals and eleven assists in fifteen appearances against the Saints in all competitions.

De Bruyne's ability to find space in the final third will likely prove troublesome for Southampton's porous defense.

His set-piece responsibilities further enhance his scoring opportunities against a team that has struggled with defensive organization all season.

With Manchester City needing every win to secure the title, expect De Bruyne to continue his outstanding form against his favorite Premier League opposition.

Key stats

1
Man City sit 3rd in the table with 64 points, while Southampton are anchored to the bottom in 20th with only 11 points.
2
Southampton have lost 28 of their 35 matches and have the worst defensive record in the league, conceding 82 goals.
3
Man City are in strong form with four wins and a draw in their last five matches (WWWWD), compared to Southampton's troubling LLDLL run.
4
There's a massive goal difference disparity: City at +24 (67 scored, 43 conceded) versus Southampton's -57 (25 scored, 82 conceded).