Celtics vs 76ers Prediction, Odds & Game Preview 3/6/2025

The red-hot Boston Celtics face an interesting test against the Philadelphia 76ers tonight, with both teams dealing with significant roster challenges - the Celtics potentially missing their big three of Tatum, Holiday, and Porzingis while the Sixers continue their campaign without Embiid, Maxey, and George.

Fresh off a spectacular shooting display where Pritchard and White combined for 84 points against Portland, Boston's depth players have shown they can step up when called upon, though fatigue could be a factor on the second night of a back-to-back.

The TD Garden crowd will watch a very different matchup than expected when the home team Celtics (44-18) take on the away team Sixers (21-40) in what could be an unexpectedly competitive Eastern Conference clash.

Boston Celtics vs. Philadelphia 76ers preview

The struggling 76ers limp into TD Garden for what's shaping up to be a David vs. Goliath matchup against a red-hot Celtics squad that's been crushing it at home.

Philly's been hit hard by the injury bug, with their star quartet of Embiid, Maxey, George, and McCain all sidelined, forcing them to lean heavily on the surprising emergence of Quentin Grimes, who dropped 30 in their last outing.

Boston's depth was on full display last night when Payton Pritchard and Derrick White put on an absolute clinic against Portland, combining for a ridiculous 84 points while their stars watched from the bench.

The Celtics' three-point barrage has been their bread and butter this season - they're leading the league in threes made, and they just showed they can rain fire even without Tatum and Porzingis in the lineup.

These Atlantic Division rivals met just two weeks ago, with Boston cruising to a 20-point win on Philly's home court, but the Sixers' young guns have been keeping games surprisingly competitive despite their brutal losing streak.

While Boston's dealing with their own injury concerns and potential fatigue from last night's shootout, their depth and home-court advantage make this feel like a tough mountain for the depleted Sixers to climb.